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June 20, 2024
Original Investigation

Perioperative Modified FOLFIRINOX for Resectable Pancreatic Cancer: A Nonrandomized Controlled Trial

Abstract Full Text
open access
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1575

This nonrandomized controlled trial assesses whether neoadjuvant modified 5-fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) leads to early control of micrometastasis and improves survival.

Performance of Tumor Surveillance for Children With Cancer Predisposition

Abstract Full Text
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1878

This cohort study evaluates surveillance outcomes across a wide spectrum of cancer predisposition syndromes in children and young adults.

Survival in Patients With Recurrent Intermediate-Stage Hepatocellular Carcinoma: Sorafenib Plus TACE vs TACE Alone Randomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1831

This randomized clinical trial evaluates the efficacy and safety of transarterial chemoembolization (TACE) plus sorafenib vs TACE alone for patients with recurrent intermediate-stage hepatocellular carcinoma.

Postrecurrence Treatment in Neoadjuvant or Adjuvant FDA Registration Trials: A Systematic Review

Abstract Full Text
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1569

This systematic review examines the proportion and quality of postrecurrence treatment among patients in US Food and Drug Administration (FDA) registration trials of anticancer therapy in the neoadjuvant or adjuvant setting.

Review

Current Management of Desmoid Tumors: A Review

Abstract Full Text
has active quiz
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1805

This review describes the process of updating the global evidence-based consensus guideline on management of desmoid tumor.

Invited Commentary

The Sequencing Conundrum in Localized Pancreatic Adenocarcinoma—Progress or Passive Acceptance?

Abstract Full Text
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.0870
Poetry and Oncology

Piercing the Fog

Abstract Full Text
JAMA Oncol. Published online June 20, 2024. doi:10.1001/jamaoncol.2024.1865
June 13, 2024
Original Investigation

Circulating Tumor DNA-Guided De-Escalation Targeted Therapy for Advanced Non−Small Cell Lung Cancer: A Nonrandomized Clinical Trial

Abstract Full Text
open access
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1779

This nonrandomized clinical trial assesses the feasibility of using a circulating tumor DNA−guided adaptive de-escalation tyrosine kinase inhibitor strategy in patients with advanced non−small cell lung cancer to achieve complete remission after local consolidative therapy.

Stereotactic Ablative Radiotherapy for Gynecological Oligometastatic and Oligoprogessive Tumors

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1796

This cohort study evaluates the outcomes of stereotactic ablative radiotherapy in patients with oligometastatic and oligoprogressive gynecologic cancers.

Home Time Among Older Adults With Acute Myeloid Leukemia Following Chemotherapy

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1823

This retrospective cohort study quantifies and compares home time for older patients with newly diagnosed acute myeloid leukemia receiving either hypomethylating agents or anthracycline-based chemotherapy.

Viewpoint

Sexual Rehabilitation Needs of Gay and Bisexual Men With Cancer

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1586

This Viewpoint discusses the importance of concentrating research efforts and clinical training on sexual and gender minority individuals who survive cancer, particularly on sexual rehabilitation.

Comment & Response

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1693

Valid Analysis of Brain-Specific Progression-Free Survival

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1696

Valid Analysis of Brain-Specific Progression-Free Survival—Reply

Abstract Full Text
JAMA Oncol. Published online June 13, 2024. doi:10.1001/jamaoncol.2024.1699
June 6, 2024
Original Investigation

Comprehensive Audiologic Analyses After Cisplatin-Based Chemotherapy

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1233

This cohort study evaluates cisplatin-related hearing loss with comprehensive audiologic assessments, assesses the longitudinal progression of cisplatin-related hearing loss, and identifies factors associated with risk.

Cardiovascular Events and Androgen Receptor Signaling Inhibitors in Advanced Prostate Cancer: A Systematic Review and Meta-Analysis

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1549

This systematic review and meta-analysis investigates the incidence of cardiovascular events with addition of novel androgen receptor signaling inhibitors (ARSI) to standard of care in locally advanced and metastatic prostate cancer.

Neoadjuvant Nivolumab Plus Chemotherapy Followed By Response-Adaptive Therapy for HPV+ Oropharyngeal Cancer: OPTIMA II Phase 2 Open-Label Nonrandomized Clinical Trial

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1530

This phase 2 nonrandomized clinical trial evaluates effectiveness and tolerance of neoadjuvant nivolumab, nab-paclitaxel, and carboplatin followed by response-adaptive therapy in patients with human papillomavirus−positive oropharyngeal cancer.

JAMA Oncology Clinical Challenge

Lymphoma With a Skin Rash

Abstract Full Text
has active quiz
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1558

A 62-year-old female had a generalized vesiculobullous rash on her face for 4 months. It started over the lips and gradually progressed to involve the oral mucosa and skin of the whole body. What is your diagnosis?

Viewpoint

Radiation With Immunotherapy May Be a Double-Edged Sword—How Can We Learn From Recent Negative Clinical Trials?

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1527

This Viewpoint explains differences between recent studies using radiotherapy with immunotherapy and possible reasons for their different outcomes.

Invited Commentary

Cardiovascular Risk in Prostate Cancer—A Call to Action?

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.0860
Comment & Response

Immunotherapy For US Patients With Metastatic Cancer at the End of Life

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1563

Immunotherapy For US Patients With Metastatic Cancer at the End of Life—Reply

Abstract Full Text
JAMA Oncol. Published online June 6, 2024. doi:10.1001/jamaoncol.2024.1566
June 3, 2024
Original Investigation

Assessing the Environmental and Downstream Human Health Impacts of Decentralizing Cancer Care

Abstract Full Text
JAMA Oncol. Published online June 3, 2024. doi:10.1001/jamaoncol.2024.2744

This cohort study assesses potential reductions in greenhouse gas emissions and downstream health harms associated with telemedicine and fully decentralized cancer care.

Research Letter

Geographic Distribution of Clinical Trials for Advanced-Stage Cancer

Abstract Full Text
open access
JAMA Oncol. Published online June 3, 2024. doi:10.1001/jamaoncol.2024.1690

This quality improvement study evaluates the geographic distribution of clinical trials and assesses the distances patients with cancer must travel to access a clinical trial site.

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